Dissolve contents of one packet into 8-16 fluid ounces of any liquid or food (less than 100 degrees F). Consume within 12 hours of mixing. Recommended Dosage: Consume 1 packet every other day to maintain healthy intestinal balance. Consume 1 or more packets daily, if desired or needed. No refrigeration is required. Recommended for all ages. Note: During first days of use, as bacteria in the digestive tract rebalance, temporary bloating, digestive gurgling and gas may occur, but normally subsides within on week.